Tricarbonylrhenium (I) complexes of phosphine-derivatized amines, amino acids and a model peptide: structures, solution behavior and cytotoxicity

J Zhang, JJ Vittal, W Henderson, JR Wheaton…

Index: Zhang, Jianyong; Vittal, Jagadese J.; Henderson, William; Wheaton, Jessica R.; Hall, Iris H.; Hor, T.S.Andy; Yan, Yaw Kai Journal of Organometallic Chemistry, 2002 , vol. 650, # 1-2 p. 123 - 132

Full Text: HTML

Citation Number: 74

Abstract

Modified Mannich reactions of amines, amino acids and a model peptide with Ph2PH and CH2O gave bis (diphenylphosphinomethyl) amines (Ph2PCH2) 2NR [R= Ph (1), CH2CH2OH (2), CH2COOCH2Ph (3), CH2CONHCH2COOCH2Ph (4), CH2COOH (5)] and (Ph2PCH2) 2NCH2CH2N (CH2PPh2) 2 (6). Reaction with [ReBr3 (CO) 3] 2− under mild conditions led to [ReBr (CO) 3]{(Ph2PCH2) 2NR}[R= Ph (7), CH2CH2OH (8), ...