Effects of piperine analogues on stimulation of melanocyte proliferation and melanocyte differentiation

R Venkatasamy, L Faas, AR Young, A Raman…

Index: Venkatasamy, Radhakrishnan; Faas, Laura; Young, Antony R.; Raman, Amala; Hider, Robert C. Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 8 p. 1905 - 1920

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Citation Number: 63

Abstract

A wide range of piperine analogues has been synthesised in order to undertake a structure– activity study of their ability to stimulate melanocyte proliferation. Results demonstrate that an aromatic ring containing at least one ether function and a carbonyl group containing side chain is essential for this activity. A number of highly active piperine analogues have been identified, for instance 1-(3, 4-methylenedioxyphenyl)-penta-2E, 4E-dienoic acid methyl ...