Synthesis and antiproliferative activities of diversely substituted glycosyl-isoindigo derivatives

…, F Bouchikhi, S Messaoudi, F Anizon, E Debiton…

Index: Sassatelli, Mathieu; Bouchikhi, Fadoua; Messaoudi, Samir; Anizon, Fabrice; Debiton, Eric; Barthomeuf, Chantal; Prudhomme, Michelle; Moreau, Pascale European Journal of Medicinal Chemistry, 2006 , vol. 41, # 1 p. 88 - 100

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Citation Number: 47

Abstract

In the course of structure–activity relationship studies, diversely substituted 1-(β-d- glucopyranosyl)-isoindigo derivatives were prepared from commercially available indolines. Their antiproliferative activities were evaluated toward a panel of human solid cancer cell lines (PC 3, DLD-1, MCF-7, M4Beu, A549, PA 1), a murine cell line (L929) and a human fibroblast primary culture to get an insight into the substitution pattern required for the best ...