Abstract In an effort to develop potent anti-cancer chemopreventive agents that act on topoisomerase II, a novel series of bisindolylalkanes analogues such as 3, 3′-(thiochroman- 4, 4-diyl) bis (1H-indole) are synthesized. Structures of all compounds are elucidated by 1 H NMR, 13 C NMR and HRMS. Anti-proliferative activities for all of these compounds are investigated by the method of MTT assay on 7 human cancer lines. Most of them showed ...
