Tetrahedron

Copper-mediated alkylation of vitamin D C-ring. Synthesis of C11-functionalized 1α, 25-dihydroxyvitamin D 3

M Torneiro, Y Fall, L Castedo, A Mouriño

Index: Torneiro, Mercedes; Fall, Yagamare; Castedo, Luis; Mourino, Antonio Tetrahedron, 1997 , vol. 53, # 31 p. 10851 - 10870

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Citation Number: 13

Abstract

This work describes our studies on the functionalization at C11 of CD-ring fragments of vitamin D3 using organocopper reagents. As an application, an efficient, convergent synthesis of 11α-[3, 3-(dimethoxy) propyl] calcitriol analogue 2, which may be useful for the construction of affinity columns for the purification of 1α, 25-(OH) 2-vitamin D3 receptors, is described.