A one-step synthesis of 2, 4-unsubstituted quinoline-3-carboxylic acid esters from o-nitrobenzaldehydes

H Venkatesan, FM Hocutt, TK Jones…

Index: Venkatesan, Hariharan; Hocutt, Frances M.; Jones, Todd K.; Rabinowitz, Michael H. Journal of Organic Chemistry, 2010 , vol. 75, # 10 p. 3488 - 3491

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Citation Number: 26

Abstract

A straightforward and efficient one-step procedure for the synthesis of 2, 4-unsubstituted quinoline-3-carboxylic acid ethyl esters is described. The simple reductive cyclization is carried out by treating various substituted o-nitrobenzaldehydes with inexpensive, commercially available 3, 3-diethoxypropionic acid ethyl ester and SnCl2· 2H2O in refluxing ethanol.