The Journal of Organic Chemistry

Synthesis of Potential Anticancer Agents. VI. Urea and Thiourea Mustards1, 2

FD Popp, H Swarz

Index: Popp,F.D.; Swarz,H. Journal of Organic Chemistry, 1961 , vol. 26, p. 4764 - 4765

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Citation Number: 5

Abstract

Diethylmaleic acid has only been reported as its anhydride6 and dichloro-and dibromomaleic acid readily lose water. However cyclohex-lene-l,% dicarboxylic anhydride is reporteda to be less readily hydrolyzed but lesv readily formed, suggesting that the steric effect of the substituents is less when constrained in a ring.