Preparation of d, l-Phenylalanine by Amidocarbonylation of Benzyl Chloride

JG de Vries, RP de Boer, M Hogeweg…

Index: De Vries, Johannes G.; De Boer, Rene P.; Hogeweg, Marjo; Gielens, Esther E. C. G. Journal of Organic Chemistry, 1996 , vol. 61, # 5 p. 1842 - 1846

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Citation Number: 18

Abstract

The preparation of d, l-phenylalanine via amidocarbonylation of benzyl chloride with acetamide and CO/H2 is described. The rate of the reaction is dependent upon the CO pressure below 250 bar, but independent of the hydrogen pressure. A reaction temperature of 100° C gives optimum yields. A relatively large amount of the catalyst, Co2 (CO) 8, is needed for complete conversion because of inhibition caused by hydrogen chloride which ...