The recent discovery of selective non-peptide substance P antagonists, such as CP-96,345 (1), l together with the availability of the cloned human NK1 receptor2 has led to an intense exploration of the pharmacology of substance P. Subsequently, several non-peptide antagonists from structurally different classes have been identified, including the quinuclidinium-based SR 140333 (2), 3 piperidine CP 99,994 (3), 4 the tryptophan L- ...
[Michael, Joseph P.; De Koning, Charles B.; Van der Westhuyzen, Christiaan W.; Fernandes, Manuel A. Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 17 p. 2055 - 2062]
