Tetrahedron

Total synthesis of colchicine modelled on a biogenetic theory

AI Scott, F McCapra, RL Buchanan, AC Day…

Index: Scott,A.I. et al. Tetrahedron, 1965 , vol. 21, p. 3605 - 3631

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Citation Number: 39

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A five step synthesis of desacetamidocolchiceine (XLVI) is described in which rings A and C are joined by oxidative coupling of the tropolone system. This completes a biogenetic-type total synthesis of colchicine (I). ... For early reports on medicinal and physiological effects of ...