Chloroformamidinium salts: Efficient reagents for preparation of 2??aminobenzoimidazole, 2??aminobenzoxazole, and 2??aminobenzothiazole derivatives

…, M Chebbo, M Abdul??Ghani, G Younes

Index: El-Faham, Ayman; Chebbo, Mohamed; Abdul-Ghani, Mohamed; Younes, Ghassan Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 3 p. 599 - 606

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Citation Number: 20

Abstract

A Reaction involving chloroformamidinium salts (TCFH 1a, BTCFH 1b, DmCFH 1c, DmPCFH 1d, BPCFH 1e) and 2-aminophenol 9a, benzene-1, 2-diamine 9b, and 2- aminothiophenol 9c afforded 2-aminobenzoxazole 13, 2-aminobenzoimidazole 14, and 2- aminobenzothiazole 15 derivatives, respectively as major products, due to the in situ heterocyclization with dimethylamine acting as the better leaving group. Attempts for ...