Chiral (. beta.-aminoalkyl) phosphines. Highly efficient phosphine ligands for catalytic asymmetric Grignard cross-coupling

…, M Konishi, M Fukushima, K Kanehira…

Index: Hayashi, Tamio; Konishi, Mitsuo; Fukushima, Motoo; Kanehira, Koichi; Hioki, Takeshi; Kumada, Makoto Journal of Organic Chemistry, 1983 , vol. 48, # 13 p. 2195 - 2202

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Citation Number: 197

Abstract

New chiral (0-aminoalkyl) phosphines, RCH (NMe2) CH2PPh2 [R= Me (Alaphos), i-Bu (Leuphos), PhCH2 (Phephos), i-Pr (Valphos), see-Bu (Ilephos), Ph (PhGlyphos), c-Hex (ChGlyphos), and t-Bu (t-Leuphos)], were prepared by starting with optically active amino acids. The phosphines were used as ligands for nickel-catalyzed asymmetric cross-coupling of 1-arylethyl Grignard reagents (ArMeCHMgCl) with vinyl bromide. Coupling products of ...