Phosphorus-nitrogen compounds. 24. Phosphoramide mustard carrier derivatives

…, VS Li, DR Powell, D Van der Helm

Index: Cates, Lindley A.; Li, Ven-Shun; Powell, Douglas R.; Helm, Dick van der Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 397 - 401

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Citation Number: 12

Abstract

Diethylstilbestrol, psoralen, and propranolol were used as potential carrier molecules for selective concentrations of a nitrogen mustard moiety in breast, skin, and lung tissues, respectively. The propranolol derivative gave two racemic mixtures, which were tested to ascertain any differences in anticancer activity. The insertion of a P= O group between the carrier and oncolytic portions offsets the excess lipophilic contribution of the latter and ...