Journal of medicinal chemistry

In the search for new anticancer drugs. 9. Synthesis and anticancer activity of spin-labeled analogs of N, N: N', N': N", N"-tris (1, 2-ethanediyl) phosphoric triamide and …

G Sosnovsky, BD Paul

Index: Sosnovsky, George; Paul, Buddha D. Journal of Medicinal Chemistry, 1984 , vol. 27, # 6 p. 782 - 788

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Citation Number: 16

Abstract

A number of N, N: N', N'”'', N''-tri-l, 2-ethanediylphosphoric triamide (TEPA) and N, NN', Nf: N '', N''-tri-1, 2-ethanediylphosphorothioic triamide (thio-TEPA) derivatives containing either two aziridine moieties (la) or two (2-chloroethy1) amino functions (1 b) and either a 2, 2, 6, 6- tetramethylpiperidine, l-oxy-2, 2, 6, 6-tetramethylpiperidine or l-hydroxy-2, 2, 6, 6- tetramethylpiperidine component were synthesized and tested against lymphocytic ...