Fatty acyl amide derivatives of doxorubicin: Synthesis and in vitro anticancer activities

BS Chhikara, NS Jean, D Mandal, A Kumar…

Index: Chhikara, Bhupender S.; St. Jean, Nicole; Mandal, Deendayal; Kumar, Anil; Parang, Keykavous European Journal of Medicinal Chemistry, 2011 , vol. 46, # 6 p. 2037 - 2042

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Citation Number: 28

Abstract

Doxorubicin is extensively used in anticancer therapy. Doxorubicin is highly hydrophilic, has short half-life, and its use is associated with severe side effects at high doses. Fatty acyl amide derivatives of doxorubicin were synthesized with the expectation to improve the lipophilicity and anticancer activity of the drug. The lipophilicity was enhanced with the increase in chain length of fatty acyl moiety. Conjugation of 4′-amino group with fatty ...