Anti-tubercular agents. Part 3. Benzothiadiazine as a novel scaffold for anti-Mycobacterium activity

A Kamal, KS Reddy, SK Ahmed, MNA Khan…

Index: Kamal, Ahmed; Srinivasa Reddy; Kaleem Ahmed; Khan, M. Naseer A.; Sinha, Rakesh K.; Yadav; Arora, Sudershan K. Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 3 p. 650 - 658

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Citation Number: 48

Abstract

In an effort to develop new and more effective therapies to treat tuberculosis, a series of benzothiadiazine 1, 1-dioxide derivatives were synthesized and their in vitro activity against Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium intracellulare was evaluated. One of the compounds, 8c, exhibited potent anti-tubercular activity, particularly for the resistant strains and thus prompted us to investigate its in vivo profile. However, the in ...

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