Structure–Activity Relationships of New 1??substitutedmethyl??4??[5??(N??methyl??N??propylamino) pentyloxy] piperidines and Selected 1??[(N??substituted??N??methyl)??3?? …

I Masłowska??Lipowicz…

Index: Maslowska-Lipowicz, Iwona; Walczynski, Krzysztof Chemical Biology and Drug Design, 2014 , vol. 83, # 1 p. 106 - 118

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Abstract

Novel, potent non-imidazole histamine H3 receptor antagonists have been prepared and in vitro tested as H3-receptor antagonists(the electrically evoked contraction of the guinea-pig jejunum). The present compounds contain a 4-hydroxypiperidine core, which behaves as a conformationally restricted version of the 3-amino-1-propanol moiety common to the many previously described non-imidazole H3 ligands. Detailed structure-activity studies ...