Synthesis of 3, 4-dihydro-4-oxothieno [2, 3-d] pyrimidine-2-carboxylates, a new series of orally active antiallergy agents

…, CA Hanning, RJ Seidehamel, HK Mackey…

Index: Temple; Yevich; Covington; Hanning; Seidehamel; Mackey; Bartek Journal of Medicinal Chemistry, 1979 , vol. 22, # 5 p. 505 - 510

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Citation Number: 46

Abstract

A series of novel 3, 4-dihydro-4-oxothieno [2, 3-d] pyrimidine-2-carboxylic acid derivatives has been prepared and tested for antiallergenic activity. Members of the series, including both carboxylic acid salts and esters, have been found to exhibit oral activity in the rat passive cutaneous anaphylaxis (PCA) test. Activity is optimized by H or CH3 substitution at the 5 position and lower alkyl groups at the 6 position. Ethyl 6-ethyl-3, 4-dihydro-4- ...