In connection with our efforts in searching for better antimalarial agents, three analogues of la were synthesized and evaluated for their antimalarial activity. These compounds (2a-c) are so designed that only the lipophilicity of the original compound is modified. The important triangular feature, composed of three electronegative atoms substituted at positions 1, 2, and 4 of a benzene ring, which is common to many compounds possessing ...
![2-[4-[(6-methoxy-4-methylquinolin-8-yl)amino]hexyl]isoindole-1,3-dione Structure](https://image.chemsrc.com/caspic/493/76367-79-8.png)