… condensation of Biginelli thiones, chloroacetic acid, and aldehydes as an effective approach towards thiazolo [3, 2??a] pyrimidines and 5??arylidenethiazolidine??2, 4?? …

IO Lebedyeva, MV Povstyanoy…

Index: Lebedyeva, Iryna O.; Povstyanoy, Mykhaylo V.; Ryabitskii, Aleksey B.; Povstyanoy, Vyacheslav M. Journal of Heterocyclic Chemistry, 2010 , vol. 47, # 2 p. 368 - 372

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Citation Number: 12

Abstract

Multicomponent reactions (MCRs) have been widely used in organic and medicinal chemistry over the last years for producing a number of libraries for bioscreening [1]. A three- component condensation of aromatic aldehydes with ureas (thioureas) and b-ketoesters known as Biginelli reaction [2] takes an important place among MCRs. The reaction allows forming a dihydropyrimidine cycle where the nature of the subsistent in the basic structure ...