Highly efficient C–C coupling reactions using metallated benzylphosphine complexes of palladium

…, GR Eastham, RP Tooze, DJ Cole-Hamilton

Index: Gibson; Foster; Eastham; Tooze; Cole-Hamilton Chemical Communications, 2001 , # 8 p. 779 - 780

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Citation Number: 5

Abstract

The reaction of 4-bromoacetophenone with n-butyl acrylate consistently resulted in reasonable yields of 85–90% when 2 × 10 −4 mol% of 5a was used. As expected, longer reaction times were required to achieve the same yield when a lower reaction temperature was used (entry 2). It is noted that higher temperature (170 °C, entry 1) is required to achieve activity comparable to the Herrmann system (1000000 TON in 24 h at 130 °C), 5 but no additive/promoting salts (eg. ...