A new series of hybrids of lamellarin D and combretastatin A 4, 1, 2-diphenyl-5, 6- dihydropyrrolo [2, 1-a] isoquinolines, were designed as cytotoxic agents based on principles of combination in medicinal chemistry and taking the parent compounds' different anti- proliferative mechanisms into consideration. Twenty-two novel hybrids were synthesized through a convenient route, with a key step of core pyrrole formation and evaluated for ...
