Design, synthesis, and inhibition of platelet aggregation for some 1-o-chlorophenyl-1, 2, 3, 4-tetrahydroisoquinoline derivatives

…, WY Hua, FX Wang, ZY Wang, X Wang

Index: Yang, Jie; Hua, Wei-Yi; Wang, Fu-Xiang; Wang, Zhi-Yuan; Wang, Xiang Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 24 p. 6547 - 6557

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Citation Number: 33

Abstract

Based on ticlopidine active as an ADP receptor antagonist for inhibiting platelet aggregation in clinical test, and upon finding (±)-1, 2-substituted-7-sulfonylamide/amide-1, 2, 3, 4- tetrahydroisoquinoline (11–31) inhibited of platelet aggregation, a series of (±)-1-o- chlorophenyl-2-substituted-tetrahydroisoquinoline derivatives was designed and synthesized. Four analogs proved to be potential antiplatelet aggregation agents, and ...