Safe and Efficient Reductive Methylation of Primary and Secondary Amines Using N-Methylpyrrolidine Zinc Borohydride

H Alinezhad, M Tajbakhsh, F Salehian…

Index: Alinezhad, Heshmatollah; Tajbakhsh, Mahmood; Salehian, Fatemeh; Fazli, Kazem Synthetic Communications, 2010 , vol. 40, # 16 p. 2415 - 2420

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Citation Number: 6

Abstract

An efficient, general procedure for reductive methylation of primary and secondary amines with 37% formaldehyde using N-methylpyrrolidine zinc borohydride (ZBHNMP) as a reducing agent gave the corresponding tertiary amines in excellent yields. The reaction was carried out in tetrahydrofuran under neutral conditions at 0–10° C.

~92%

~91%

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