Chemical Development of the Casein Kinase I-Epsilon Inhibitor: 3-(3-Fluorophenyl) sulfanyl-1 H-pyrrolo [3, 2-b] pyridine-2-carboxylic Acid Amide

BG Huang, G Kubiak, JJ Shay…

Index: Organic Process Research and Development, , vol. 15, # 5 p. 1040 - 1045

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Abstract

... Organic Process Research & Development. ... was reported to provide 2-methyl-3-nitropyridine in 63% yield after vacuum distillation.(9) The procedure used to ... A process with a better safety profile was developed using diethyl malonate and a base (Scheme 2). After a base ...