New strong fibrates with piperidine moiety.

…, H Hirota, M Otsuka, J Kotake, S Hasegawa…

Index: Komoto, Teruo; Hirota, Hiroyuki; Otsuka, Mari; Kotake, Jiro; Hasegawa, Susumu; Koya, Hidehiko; Sato, Susumu; Sakamoto, Takao Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 12 p. 1978 - 1985

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Citation Number: 12

Abstract

New fibrates containing piperidine, 4-hydroxypiperidine, piperidin-3-ene, and piperazine moieties in the structures were synthesized and evaluated. Among the synthesized compounds, 2-[3-[1-(4-fluorobenzoyl)-piperidin-4yl] phenoxy]-2-methylpropanoic acid (9aA: AHL-157) showed very superior activities in decreasing triglyceride, cholesterol, and blood sugar compared to bezafibrate in mice and rats.

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