Design and synthesis of highly potent and selective human peroxisome proliferator-activated receptor α agonists

Y Yamazaki, K Abe, T Toma, M Nishikawa…

Index: Yamazaki, Yukiyoshi; Abe, Kazutoyo; Toma, Tsutomu; Nishikawa, Masahiro; Ozawa, Hidefumi; Okuda, Ayumu; Araki, Takaaki; Oda, Soichi; Inoue, Keisuke; Shibuya, Kimiyuki; Staels, Bart; Fruchart, Jean-Charles Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4689 - 4693

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Citation Number: 26

Abstract

A combination of benzoxazole, phenoxyalkyl side chain, and phenoxybutyric acids was identified as a highly potent and selective human peroxisome proliferator-activated receptor α (PPARα) agonist. The synthesis, structure–activity relationship (SAR) studies, and in vivo activities of the representative compounds are described.