22-Hydroxycholesterol derivatives as HMG CoA reductase suppressors and serum cholesterol lowering agents

RJ Chorvat, BN Desai, SE Radak…

Index: Chorvat, Robert J.; Desai, Bipin N.; Radak, Suzanne Evans; McLaughlin, Kathleen T.; Miller, James E.; et al. Journal of Medicinal Chemistry, 1985 , vol. 28, # 2 p. 194 - 200

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Citation Number: 10

Abstract

A series of 22-hydroxycholestero1 derivatives with a modified side chain terminus was prepared. These agents were evaluated in vitro and in vivo for their ability to suppress HMG CoA reductase, the rate-limiting enzyme of cholesterol biosynthesis. In tissue culture assays, 22-hydroxycholestero1 as well as the side chain modified analogues were potent inhibitors of HMG CoA reductase. However, only those sterols with a modified side chain terminus ...