Synthesis of C8 N9 Annulated Purines by Iron??Catalyzed C H Amination

J Maes, TRM Rauws, BUW Maes

Index: Maes, Jens; Rauws, Tom R. M.; Maes, Bert U. W. Chemistry - A European Journal, 2013 , vol. 19, # 28 p. 9137 - 9141

Full Text: HTML

Citation Number: 14

Abstract

Purine derivatives display a wide variety of biological activities and the purine nucleus has been used as a template for addressing a variety of biological targets.[1, 2] Not surprisingly, the development of efficient functionalization processes for the purine nucleus is a very active area of research.[3, 4] The biggest challenge in obtaining good purine-based enzyme inhibitors and receptor (ant) agonists is to overcome the lack of selectivity for a specific ...