Reaction of 2??dimethylaminomethylene??1, 3??diones with dinucleophiles. VIII. Synthesis of ethyl and methyl 2, 4??disubstituted 5??pyrimidinecarboxylates

P Schenone, L Sansebastiano…

Index: Schenone, Pietro; Sansebastiano, Laura; Mosti, Luisa Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 2 p. 295 - 305

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Citation Number: 46

Abstract

Abstract Reaction of ethyl or methyl 2-dimethylaminomethylene-3-oxoalkanoates with NCN dinucleophiles such as guanidine, acetamidine or benzamidine afforded in high yields the relative esters of 4-substituted 2-amino-, 2-methyl-or 2-phenyl-5-pyrimidinecarboxylic acids, respectively. These esters were hydrolyzed to the corresponding carboxylic acids, which were converted by heating to 4-substituted 2-pyrimidinamines, 2-methyl or 2- ...

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