A new and convenient synthesis of alkyl and aryl pyrimidines

…, A Herrera, R Martinez, E Teso, A Garcia…

Index: Martinez, A. Garcia; Herrera, A.; Martinez, R.; Teso, E.; Garcia, A.; et al. Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 1237 - 1241

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Citation Number: 23

Abstract

Abstract Vinyl triflates 1, which are obtained easily from the corresponding ketones, react in an excess of pure nitrile (80/20 hours) to form tri-and tetra-substituted alkyl and arylpyrimidines 4 and 5 in good yields (45–87%). An isomeric mixture of pyrimidines 4 and 5 is formed from Inflate 1 when R 1≠ R 2≠ H. The reaction proceeds by nitrile-catalyzed elimination-addition mechanism.