Sulfonamides containing coumarin moieties selectively and potently inhibit carbonic anhydrases II and IX: design, synthesis, inhibitory activity and 3D-QSAR analysis

…, X Zhang, HY Qiu, YT Duan, YT Wang, YL Sang…

Index: Wang, Zhong-Chang; Qin, Ya-Juan; Wang, Peng-Fei; Yang, Yong-An; Wen, Qing; Zhang, Xin; Qiu, Han-Yue; Duan, Yong-Tao; Wang, Yan-Ting; Sang, Ya-Li; Zhu, Hai-Liang European Journal of Medicinal Chemistry, 2013 , vol. 66, p. 1 - 11

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Citation Number: 11

Abstract

Abstract A series of sulfonamides containing coumarin moieties had been prepared that showed a very interesting profile for the inhibition of two human carbonic anhydrase inhibitors. These compounds were evaluated for their ability to inhibit the enzymatic activity of the physiologically dominant isozymes hCA II and the tumor-associated isozyme hCA IX. The most potent inhibitor against hCA II and IX were compounds 5d (IC 50= 23 nM) and 5l ...