The Journal of organic chemistry

Synthesis and Properties of a New Member of the Calixnaphthalene Family: AC 2-Symmetrical endo-Calix [4] naphthalene

S Chowdhury, PE Georghiou

Index: Chowdhury, Sultan; Georghiou, Paris E. Journal of Organic Chemistry, 2002 , vol. 67, # 19 p. 6808 - 6811

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Citation Number: 19

Abstract

The synthesis of a new endo-calix [4] naphthalene is described. The reaction sequence involves the cyclocondensation of a key bisnaphthylmethane intermediate (8) with formaldehyde. This key intermediate (8) is formed using a modified Suzuki-Miyaura Pd- catalyzed cross-coupling reaction between bromomethylnaphthyl (6) and naphthylboronic acid (7), both of which can be derived from 2-hydroxynaphthoic acid.