Migraine headache is a debilitating, chronic disease affecting the lives of millions of people worldwide. 1, 2 Migraine is most prevalent in working age populations (35-40 years old), and its economic impact in the United States alone has been estimated in the billions of dollars. 3, 4 Currently, the primary treatment for migraine is Sumatriptan (1), a nonselective serotonergic agent which binds with high affinity to both the 5-HT1D and 5-HT1B ...
