Tetrahedron letters

Diprotection of primary amines as N-substituted-2, 5-bis [(triisopropylsilyl) oxy] pyrroles (BIPSOP)

SF Martin, C Limberakis

Index: Martin, Stephen F.; Limberakis, Chris Tetrahedron Letters, 1997 , vol. 38, # 15 p. 2617 - 2620

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Citation Number: 12

Abstract

Primary amines are diprotected as their 2, 5-bis [(triisopropylsilyl) oxy] pyrrole derivatives (BIPSOP). This protecting group is stable to strong bases such as organolithiums and alkoxides at 0° C and to temperatures up to about 150° C. Removal may be accomplished by a mild two step sequence.