Abstract 3, 4-Diphenylbutan-2-one (III) and 3-methyl-3-phenylbutan-2-one were transformed by treatment with 3-dimethylaminopropylmagnesium chloride and 1-methyl-4- piperidylmagnesium chloride to the amino alcohols VI, VII, and X. Compound VI was dehydrated to the olefinic amine VIII, and reduced to the saturated amine IX. 2-(3-Fluoro-4- hydroxyphenyl) ethylamine (XI) was prepared by a modified route via the methoxy ...
