Phenyl thiazolyl urea and carbamate derivatives as new inhibitors of bacterial cell-wall biosynthesis

…, PJ Petersen, P Labthavikul, G Singh, Y Yang…

Index: Francisco, Gerardo D.; Li, Zhong; Albright, J. Donald; Eudy, Nancy H.; Katz, Alan H.; Petersen, Peter J.; Labthavikul, Pornpen; Singh, Guy; Yang, Youjun; Rasmussen, Beth A.; Lin, Yang-I.; Mansour, Tarek S. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 1 p. 235 - 238

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Citation Number: 46

Abstract

Over 50 phenyl thiazolyl urea and carbamate derivatives were synthesized for evaluation as new inhibitors of bacterial cell-wall biosynthesis. Many of them demonstrated good activity against MurA and MurB and gram-positive bacteria including MRSA, VRE and PRSP. 3, 4- Difluorophenyl 5-cyanothiazolylurea (3p) with clog P of 2.64 demonstrated antibacterial activity against both gram-positive and gram-negative bacteria.