Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 2: α-Branched quaternary amines

T Hunt, HC Atherton-Watson, SP Collingwood…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 8 p. 2877 - 2879

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Citation Number: 13

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... 1 Current marketed therapeutics only target the infection and inflammation symptoms of CF, as such there is an unmet medical need for novel treatments that address the underlying cause of CF. ...