A method is described for the synthesis of Nα-protected bi-and trifunctional amino acid p- nitroanilides. The reaction uses phosphorus oxychloride as the condensing agent. The synthesis is simple, rapid, free of racemization and affords yields between 70–90%. The synthesis can be performed not only with amino acid derivatives of the urethane type including acid-labile (Z. Boc) and base-labile (Fmoc, Msc) Nα-proteclivc functions or allyl- ...
