Synthesis and Bioactivity of Novel Adamantyl Derivatives as Potent MDR Reversal Agents

R Naik, C Jeon, H Min, HK Choi, KH Min…

Index: Naik, Ravi; Jeon, Chanoh; Min, Hyeyoung; Choi, Hyun Kyung; Min, Kyung Hoon; Lee, Kyeong Bulletin of the Korean Chemical Society, 2011 , vol. 32, # 12 p. 4444 - 4446

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Citation Number: 2

Abstract

Multidrug Resistance (MDR) is a type of resistance of tumor cells to various kinds of chemotherapeutic drugs which are structurally unrelated and also one of the major impediments to chemotherapeutic treatment of cancer. 1-4 It has been reported that 49 ATP- binding cassette (ABC) transporter genes are present in the human genome. Among them, over-expression of P-glycoprotein (P-gp), encoded by MDR1 gene is one of the major ...