Semisynthesis, ex vivo evaluation, and SAR studies of coumarin derivatives as potential antiasthmatic drugs

…, G Navarrete-Vázquez, S Hidalgo-Figueroa…

Index: Sanchez-Recillas, Amanda; Navarrete-Vazquez, Gabriel; Hidalgo-Figueroa, Sergio; Rios, Maria Yolanda; Ibarra-Barajas, Maximiliano; Estrada-Soto, Samuel European Journal of Medicinal Chemistry, 2014 , vol. 77, p. 400 - 408

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Citation Number: 16

Abstract

Abstract Asthma is a chronic inflammatory disorder that causes contraction in the smooth muscle of the airway and blocking of airflow. Reversal the contractile process is a strategy for the search of new drugs that could be used for the treatment of asthma. This work reports the semisynthesis, ex vivo relaxing evaluation and SAR studies of a series of 18 coumarins. The results pointed that the ether derivatives 1–3, 7–9 and 13–15 showed the best activity ...