Structure–activity relationships and enzyme inhibition of pantothenamide-type pantothenate kinase inhibitors

…, K Hevener, HW Park, S Jackowski, CO Rock…

Index: Virga, Kristopher G.; Zhang, Yong-Mei; Leonardi, Roberta; Ivey, Robert A.; Hevener, Kirk; Park, Hee-Won; Jackowski, Suzanne; Rock, Charles O.; Lee, Richard E. Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 4 p. 1007 - 1020

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Citation Number: 46

Abstract

A set of novel pantothenamide-type analogues of the known Staphylococcus aureus pantothenate kinase (SaPanK) inhibitors, N-pentyl, and N-heptylpantothenamide, was synthesized in three series. The first series of analogues (1–3) were designed as ...