Step??Economical Synthesis of Tetrahydroquinolines by Asymmetric Relay Catalytic Friedländer Condensation/Transfer Hydrogenation

L Ren, T Lei, JX Ye, LZ Gong

Index: Ren, Lei; Lei, Tao; Ye, Jia-Xi; Gong, Liu-Zhu Angewandte Chemie - International Edition, 2012 , vol. 51, # 3 p. 771 - 774

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Citation Number: 62

Abstract

Chiral 1, 2, 3, 4-tetrahydroquinoline derivatives have found widespread application in the preparation of naturally occurring alkaloids and pharmaceutically relevant molecules.[1] Their great synthetic importance has stimulated a boom in the development of asymmetric synthetic methods.[2, 3] The most common access to this structural motif is the asymmetric reduction of quinolines.[3] Although it is straightforward, this approach requires preformed ...