Benzylimidazolines as h5-HT1B/1D serotonin receptor ligands: A structure-affinity investigation

…, V Rampersad, T Prisinzano, RA Glennon

Index: Law, Ho; Dukat, Malgorzata; Teitler, Milt; Lee, David K. H.; Mazzocco, Lucia; Kamboj, Raj; Rampersad, Vik; Prisinzano, Thomas; Glennon, Richard A. Journal of Medicinal Chemistry, 1998 , vol. 41, # 13 p. 2243 - 2251

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Citation Number: 13

Abstract

Benzylimidazolines may represent a class of 5-HT1D ligands that has yet to be exploited. On the basis of a previous report that the 2-(substituted-benzyl) imidazoline α-adrenergic agonist oxymetazoline (8) binds with high affinity at calf brain 5-HT1D receptors, we explored the structure-affinity relationships of a series of related derivatives. Each of the aromatic substituents was removed and then reinstated in a systematic manner to ...