Chemical Communications

Total synthesis of hydroxymethylacylfulvene, an antitumour derivative of illudin S

TC McMorris, Y Hu, J Yu, MJ Kelner

Index: McMorris, Trevor C.; Hu, Yi; Yu, Jian; Kelner, Michael J. Chemical Communications, 1997 , # 3 p. 315 - 316

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Citation Number: 42

Abstract

... Trevor C. McMorris,*a Yi Hu,a Jian Yua and Michael J. Kelnerb a Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA b Department of Pathology, University of California ... Treatment of 13 with 10% KOH–MeOH at 80 °C for 2 h cleaved the oxygen bridge giving the diol 14 (75% for the two steps). ... 7 MJ Kelner, TC McMorris, LA Estes, W. Wang, KM Samson and R. Taetle, Investigational New Drugs, 1996, 14, 161. ...