The Journal of Organic Chemistry

A simple asymmetric synthesis of 4-arylphenylalanines via palladium-catalyzed cross coupling reaction of arylboronic acids with tyrosine triflate

WC Shieh, JA Carlson

Index: Shieh, Wen-Chung; Carlson, John A. Journal of Organic Chemistry, 1992 , vol. 57, # 1 p. 379 - 381

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Citation Number: 127

Abstract

4-Phenylphenylalanine is present as a structural element in certain biologically active compounds; for example, the potent, long-acting angiotensin I1 antagonist.] A biphenyl residue is also present in the cyclic tripeptide antibiotic WS-43708A. 2 To our knowledge, the only chiral synthesis of 4-arylphenylalanines is that reported by Yabe3 via enzymatic resolution. Tille9 has shown that (carboalkoxyalky1) phenylalanines are obtained in high ...