Highly concise routes to epothilones: the total synthesis and evaluation of epothilone 490

K Biswas, H Lin, JT Njardarson…

Index: Journal of the American Chemical Society, , vol. 124, # 33 p. 9825 - 9832

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Citation Number: 105

Abstract

... Journal of the ... 2002, 124 (33), pp 9825–9832. DOI: 10.1021/ja0262333. Publication Date (Web): June 22, 2002. Copyright © 2002 American Chemical Society. ... The isolation of epothilone 490 (3) prompted us to reevaluate the utility of the RCM procedure for fashioning the 10,11 ...

 Related Synthetic Route
t-butyl (3S,6R,7S,8S)-3-hydroxy-5-oxo-4,4,6,8-tetramethyl-7-(2,2,2-trichloroethoxycarbonyloxy)-10-undecenoate Structure

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t-butyl (3S,6R,...

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Epothilone D Structure

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Epothilone D

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Epothilone D Structure

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Epothilone D

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Epothilone D Structure

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Epothilone D

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Epothilone D Structure

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Epothilone D

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Epothilone D Structure

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Epothilone D

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448210-81-9

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Epothilone D Structure

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Epothilone D

(4S,7R,8S,9S,11E,13Z,16S)-4-hydroxy-5,5,7,9,13-pentamethyl-16-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-2,6-dioxooxacyclohexadeca-11,13-dien-8-yl (2,2,2-trichloroethyl) carbonate Structure

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Epothilone D Structure

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Epothilone D Structure

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