Tetrahedron letters

Synthesis of optically active ring-A substituted tryptophans as IDO inhibitors

X Li, W Yin, PVVS Sarma, H Zhou, J Ma, JM Cook

Index: Li, Xiaoyan; Yin, Wenyuan; Sarma, P.V.V. Srirama; Zhou, Hao; Jun Ma; Cook, James M. Tetrahedron Letters, 2004 , vol. 45, # 46 p. 8569 - 8573

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Citation Number: 35

Abstract

Indoleamine 2,3-dioxygenase (IDO) is a monomeric cytosolic enzyme that is distributed in many human tissues including the lens, brain, lung, kidney, spleen, and in macrophages. 1 It is a heme-containing enzyme that uses superoxide or oxygen to cleave the 2,3-double bond of the pyrrole ring of l-tryptophan to yield N-formylkynurenine. This is the first and rate-determining step of the kynurenine pathway (KP), which is the major metabolic path for the breakdown ...