Tetrahedron letters

An efficient palladium catalyzed synthesis of 2-arylbenzothiazoles

VJ Majo, J Prabhakaran, JJ Mann, JSD Kumar

Index: Majo, Vattoly J.; Prabhakaran, Jaya; Mann, J. John; Kumar, J. S. Dileep Tetrahedron Letters, 2003 , vol. 44, # 47 p. 8535 - 8537

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Citation Number: 82

Abstract

A novel and convergent palladium catalyzed synthesis of 2-arylbenzothiazoles has been investigated. The key step in the synthesis is a Suzuki biaryl coupling of 2- bromobenzothiazole with aryl boronic acids to provide a variety of 2-arylbenzothiazole derivatives in good yield. The synthetic utility of this methodology is demonstrated by the synthesis of 2-(4-aminophenyl)-6-methoxybenzothiazole, a PET probe precursor for the in ...