Synlett

Copper (I) Mediated IntramolecularCyclization of 2-(2-Amino-phenylethynyl) benzoic and [2-(2-Aminophenylethynyl) phenyl] aceticAcid Esters: A New Synthetic Step …

FJ Reboredo, M Treus, JC Estevez, L Castedo…

Index: Reboredo, Francisco J.; Treus, Monica; Estevez, Juan C.; Castedo, Luis; Estevez, Ramon J. Synlett, 2003 , # 11 p. 1603 - 1606

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Citation Number: 17

Abstract

Among the most efficient procedures for indole system synthesisare methods starting from 2-ethynylaniline derivatives, which areeasily prepared and modified, and can be heteroannulated to givethe indole system by many types of reagents, among the most frequentlyused being palladium complexes [7-10] and,more recently, copper salts. [11] Aspart of a broader synthetic programme on indoles, we herein describea copper-mediated heteroannulation of o- ...